Isaac E Srulevich

2024 isaac

Isaac came from South Carolina’s Governor’s School for Science and Math. His research focused on a subclass of DES called NADES (Natural Deep Eutectic Solvents) and worked with type III NADES, which are an ammonium salt and hydrogen bond donor. NADES (and DES) are formed when, usually two solids at room temperatures, are mixed usually by heating and stirring or by other methods like vacuum evaporation. Due to the strong hydrogen bonds, the melting point drops and becomes a liquid at room temperature. This research focuses on how NADES can preserve enzyme activity and other applications. According to the results, ALP showed higher activity when used in aqueous solutions but retained about 1/3 of that activity when placed in 100% NADES. However, the enzyme remained more stable in the vials with more Glyceline, suggesting that NADES have the potential of preserving enzymes for a longer period, in comparison to water. Future research could show whether Glyceline shows the same results for other enzymes or if ALP shows better activity and stability in different NADES such as Reline(1:2 ChCl and Urea) or  Ethaline (1:2 ChCl and Ethylene Glycol) which would not hurt the environment because of their low cost and non-toxicity/biodegradability compared to Ionic Liquids or Volatile Organic Compounds which are more commonly used.

 

 

Poster presented at the 2024 Annual SPRI Poster Session Poster presented at 2024 SERMACS
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